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The skin, subcutaneous tissue, and fascia were sequentially incised, and a pencil-tipped guide rod was inserted and placed on the surface of the intervertebral space

HDACi promotes inflammatory remodeling of the tumor microenvironment to enhance epitope spreading and antitumor immunity

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The finding that TICs, rather than differentiated tumor cells, grow in 3D gels offers a unique opportunity to unveil TIC-specific signaling pathways and therapeutic targets common to various cancer types